The C. elegans SYS-1 protein is a bona fide beta-catenin.


C. elegans SYS-1 has key functional characteristics of a canonical beta-catenin, but no significant sequence similarity. Here, we report the SYS-1 crystal structure, both on its own and in a complex with POP-1, the C. elegans TCF homolog. The two structures possess signature features of canonical beta-catenin and the beta-catenin/TCF complex that could not… (More)
DOI: 10.1016/j.devcel.2008.02.015


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