The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development.

@article{Coustham2006TheCE,
  title={The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development.},
  author={Vincent Coustham and C{\'e}cile Bedet and Karine Monier and Sonia Schott and Marianthi Karali and Francesca Palladino},
  journal={Developmental biology},
  year={2006},
  volume={297 2},
  pages={308-22}
}
HP1 proteins are essential components of heterochromatin and contribute to the transcriptional repression of euchromatic genes via the recruitment to specific promoters by corepressor proteins including TIF1 and Rb. The Caenorhabditis elegans HP1 homologue HPL-2 acts in the "synMuv" (synthetic multivulval) pathway, which defines redundant negative regulators of a Ras signaling cascade required for vulval induction. Several synMuv genes encode for chromatin-associated proteins involved in… CONTINUE READING

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