The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status.

@article{Kimura2011TheCE,
  title={The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status.},
  author={Koutarou D. Kimura and Donald L. Riddle and Gary Ruvkun},
  journal={Cold Spring Harbor symposia on quantitative biology},
  year={2011},
  volume={76},
  pages={113-20}
}
A Caenorhabditis elegans insulin-like signaling pathway regulates development, metabolism, and longevity. We detected abundant DAF-2 insulin-like receptor protein mainly in the nervous system, consistent with the assignment of DAF-2 pathway regulation of longevity to the nervous system. DAF-2 abundance in the nervous system is dependent on food intake, showing environmental modulation of pathway signaling. DAF-2 abundance is not dependent on downstream PI-3 kinase to DAF-16 transcription factor… CONTINUE READING