The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells.

@article{Schreibelt2012TheCL,
  title={The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells.},
  author={Gerty Schreibelt and Lieke J. J. Klinkenberg and Luis Javier Cruz and Paul Tacken and Jurjen Tel and Martin Kreutz and Gosse J Adema and Gordon D Brown and Carl G. Figdor and I Jolanda M de Vries},
  journal={Blood},
  year={2012},
  volume={119 10},
  pages={2284-92}
}
CLEC9A is a recently discovered C-type lectin receptor involved in sensing necrotic cells. In humans, this receptor is selectively expressed by BDCA3(+) myeloid dendritic cells (mDCs), which have been proposed to be the main human cross-presenting mDCs and may represent the human homologue of murine CD8(+) DCs. In mice, it was demonstrated that antigens delivered with antibodies to CLEC9A are presented by CD8(+) DCs to both CD4(+) and CD8(+) T cells and induce antitumor immunity in a melanoma… CONTINUE READING