The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells.

@article{Cambi2003TheCL,
  title={The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells.},
  author={Alessandra Cambi and Karlijn Gijzen and l Jolanda M de Vries and Ruurd Torensma and Ben Joosten and Gosse J Adema and Mihai G Netea and B. -J. Kullberg and Luigina Romani and Carl G. Figdor},
  journal={European journal of immunology},
  year={2003},
  volume={33 2},
  pages={532-8}
}
Dendritic cells (DC) that express the type II C-type lectin DC-SIGN (CD209) are located in the submucosa of tissues, where they mediate HIV-1 entry. Interestingly, the pathogen Candida albicans, the major cause of hospital-acquired fungal infections, penetrates at similar submucosal sites. Here we demonstrate that DC-SIGN is able to bind C. albicans both in DC-SIGN-transfected cell lines and in human monocyte-derived DC. The binding was shown to be time- as well as concentration-dependent, and… CONTINUE READING

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