The C-terminus of the thromboxane receptor contributes to coupling and desensitization in a mouse mesangial cell line.

@article{Spurney1997TheCO,
  title={The C-terminus of the thromboxane receptor contributes to coupling and desensitization in a mouse mesangial cell line.},
  author={Robert F Spurney and Thomas M. Coffman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={283 1},
  pages={207-15}
}
To investigate regulatory domains of the thromboxane A2 (TxA2) receptor, we constructed a truncated form of the mouse TxA2 receptor and expressed it in a mesangial cell line. The mutant receptor lacked 22 amino acids in the C-terminus including four potential phosphorylation sites. Ligand binding of mutant receptors was identical with the wild type… CONTINUE READING