The C terminus of the synovial sarcoma-associated SSX proteins interacts with the LIM homeobox protein LHX4

@article{Bruijn2008TheCT,
  title={The C terminus of the synovial sarcoma-associated SSX proteins interacts with the LIM homeobox protein LHX4},
  author={Diederik R. H. de Bruijn and Anke H. A. van Dijk and Marieke P Willemse and A. Geurts van Kessel},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={653-662}
}
As a result of the synovial sarcoma-associated t(X;18) translocation, the SS18 gene on chromosome 18 is fused to either one of the three closely related SSX genes on the X chromosome. The SS18 protein is thought to act as a transcriptional co-activator, whereas the SSX proteins are thought to act as transcriptional corepressors. The main SSX-repression domain is located in its C terminus, a domain that is retained in the respective SS18–SSX fusion proteins. Both the SS18 and SSX proteins lack… CONTINUE READING

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