The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication.

@article{Lindenbach2007TheCT,
  title={The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication.},
  author={Brett Lindenbach and B{\'e}la M Pr{\'a}gai and Roland Montserret and Rudolf K. F. Beran and Anna M Pyle and François Penin and Charles M. Rice},
  journal={Journal of virology},
  year={2007},
  volume={81 17},
  pages={8905-18}
}
Hepatitis C virus (HCV) nonstructural protein 4A (NS4A) is only 54 amino acids (aa) in length, yet it is a key regulator of the essential serine protease and RNA helicase activities of the NS3-4A complex, as well as a determinant of NS5A phosphorylation. Here we examine the structure and function of the C-terminal acidic region of NS4A through site-directed mutagenesis of a Con1 subgenomic replicon and through biophysical characterization of a synthetic peptide corresponding to this region. Our… CONTINUE READING

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