The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover.

@article{Lu2006TheCT,
  title={The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover.},
  author={Xingwu Lu and Songmei Liu and Thomas B Kornberg},
  journal={Genes & development},
  year={2006},
  volume={20 18},
  pages={2539-51}
}
Patched (Ptc) is a membrane protein whose function in Hedgehog (Hh) signal transduction has been conserved among metazoans and whose malfunction has been implicated in human cancers. Genetic analysis has shown that Ptc negatively regulates Hh signal transduction, but its activity and structure are not known. We investigated the functional and structural properties of Drosophila Ptc and its C-terminal domain (CTD), 183 residues that are predicted to reside in the cytoplasm. Our results show that… CONTINUE READING