The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity.

@article{Gupta2004TheCT,
  title={The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity.},
  author={Sanjeev M. Gupta and R Singh and Pinaki Datta and Zhijia Zhang and Christopher Orr and Zhongmin Lu and Garrett Dubois and Antonis S. Zervos and Miriam H. Meisler and Srinivasa M. Srinivasula and Teresa Fernandes-Alnemri and Emad S. Alnemri},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 44},
  pages={
          45844-54
        }
}
Presenilin mutations are responsible for most cases of autosomal dominant inherited forms of early onset Alzheimer disease. Presenilins play an important role in amyloid beta-precursor processing, NOTCH receptor signaling, and apoptosis. However, the molecular mechanisms by which presenilins regulate apoptosis are not fully understood. Here, we report that presenilin-1 (PS1) regulates the proteolytic activity of the serine protease Omi/HtrA2 through direct interaction with its regulatory PDZ… CONTINUE READING
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