The C-terminal region of the focal adhesion kinase F1 domain binds Akt1 and inhibits pressure-induced cell adhesion.

@article{Basson2017TheCR,
  title={The C-terminal region of the focal adhesion kinase F1 domain binds Akt1 and inhibits pressure-induced cell adhesion.},
  author={Marc D. Basson and Bixi Zeng and Shouye Wang},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2017},
  volume={68 3},
  pages={375-383}
}
Increased extracellular pressure or shear stress activate a complex signal pathway that stimulates integrin binding affinity and potentiates metastatic cell adhesion. Inhibiting either focal adhesion kinase (FAK) and Akt1 can block this pathway, but risks interfering with the diverse other functions of each kinase. However, the mechanotransduced signal pathway involves a novel Akt1-FAK interaction not required for most FAK or Akt1 function, so modeling and blocking this interaction seems a… CONTINUE READING
1 Citations
0 References
Similar Papers

Similar Papers

Loading similar papers…