The C-terminal half of the α2C-adrenoceptor determines the receptor's membrane expression level and drug selectivity

Abstract

In tissues as well as in transfected cells, α2C-adrenoceptors show poorer expression levels compared to α2A-adrenoceptors. In order to characterize which regions of the α2C-adrenoceptor are involved in regulating the expression of binding-competent receptors at the plasma membrane, six chimeric α2A-/α2C-adrenoceptors were constructed. The wild-type α2A- and… (More)
DOI: 10.1007/s00210-013-0902-z

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