The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability

@article{Yankiwski2001TheCD,
  title={The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability},
  author={Victor Yankiwski and James P Noonan and Norma F Neff},
  journal={BMC Cell Biology},
  year={2001},
  volume={2},
  pages={11 - 11}
}
Bloom syndrome is a rare cancer-prone disorder in which the cells of affected persons have a high frequency of somatic mutation and genomic instability. Bloom syndrome cells have a distinctive high frequency of sister chromatid exchange and quadriradial formation. BLM, the protein altered in BS, is a member of the RecQ DNA helicase family, whose members share an average of 40% identity in the helicase domain and have divergent N-terminal and C-terminal flanking regions of variable lengths. The… CONTINUE READING

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