The C-terminal domain of Escherichia coli MutY is involved in DNA binding and glycosylase activities.

@article{Li2003TheCD,
  title={The C-terminal domain of Escherichia coli MutY is involved in DNA binding and glycosylase activities.},
  author={Lina Li and A. Lili Lu},
  journal={Nucleic acids research},
  year={2003},
  volume={31 12},
  pages={
          3038-49
        }
}
Escherichia coli MutY is an adenine and a weak guanine DNA glycosylase involved in reducing mutagenic effects of 7,8-dihydro-8-oxo-guanine (8-oxoG). The C-terminal domain of MutY is required for 8-oxoG recognition and is critical for mutation avoidance of oxidative damage. To determine which residues of this domain are involved in 8-oxoG recognition, we constructed four MutY mutants based on similarities to MutT, which hydrolyzes specifically 8-oxo-dGTP to 8-oxo-dGMP. F294A-MutY has a slightly… CONTINUE READING

Similar Papers

Figures, Tables, and Topics from this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 57 REFERENCES

Potential double-flipping mechanism by E. coli MutY.

  • Progress in nucleic acid research and molecular biology
  • 2001
VIEW 1 EXCERPT

Repair of oxidative DNA damage

  • Cell Biochemistry and Biophysics
  • 2001
VIEW 1 EXCERPT