The C-terminal domain of DNA gyrase A adopts a DNA-bending β-pinwheel fold

@inproceedings{Corbett2004TheCD,
  title={The C-terminal domain of DNA gyrase A adopts a DNA-bending β-pinwheel fold},
  author={Kevin D Corbett and Ryan K Shultzaberger and James M Berger},
  year={2004}
}
DNA gyrase is unique among enzymes for its ability to actively introduce negative supercoils into DNA. This function is mediated in part by the C-terminal domain of its A subunit (GyrA CTD). Here, we report the crystal structure of this 35-kDa domain determined to 1.75-Å resolution. The GyrA CTD unexpectedly adopts an unusual fold, which we term a -pinwheel, that is globally reminiscent of a -propeller but is built of blades with a previously unobserved topology. A large, conserved basic patch… CONTINUE READING

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