The C-terminal domain of Clostridium perfringens alpha toxin as a vaccine candidate against bovine necrohemorrhagic enteritis.

@article{Goossens2016TheCD,
  title={The C-terminal domain of Clostridium perfringens alpha toxin as a vaccine candidate against bovine necrohemorrhagic enteritis.},
  author={Evy Goossens and Stefanie Verherstraeten and Bonnie R. Valgaeren and Bart Pardon and Leen Timbermont and Stijn Schauvliege and Diego Rodrigo-Mochol{\'i} and Freddy Haesebrouck and Richard Ducatelle and Piet R. Deprez and Filip van Immerseel},
  journal={Veterinary research},
  year={2016},
  volume={47 1},
  pages={52}
}
Bovine necrohemorrhagic enteritis is caused by Clostridium perfringens and leads to sudden death. Alpha toxin, together with perfringolysin O, has been identified as the principal toxin involved in the pathogenesis. We assessed the potential of alpha toxin as a vaccine antigen. Using an intestinal loop model in calves, we investigated the protection afforded by antisera raised against native alpha toxin or its non-toxic C-terminal fragment against C. perfringens-induced intestinal necrosis… CONTINUE READING