The C-terminal domain of Brd2 is important for chromatin interaction and regulation of transcription and alternative splicing

Abstract

Brd2 is a member of the bromodomain extra terminal (BET) protein family, which consists of four chromatin-interacting proteins that regulate gene expression. Each BET protein contains two N-terminal bromodomains, which recognize acetylated histones, and the C-terminal protein-protein interaction domain. Using a genome-wide screen, we identify 1450 genes… (More)
DOI: 10.1091/mbc.E13-06-0303

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