The C-terminal domain of AcrA is essential for the assembly and function of the multidrug efflux pump AcrAB-TolC.

@article{Ge2009TheCD,
  title={The C-terminal domain of AcrA is essential for the assembly and function of the multidrug efflux pump AcrAB-TolC.},
  author={Qiang Ge and Yoichi Yamada and Helen I Zgurskaya},
  journal={Journal of bacteriology},
  year={2009},
  volume={191 13},
  pages={4365-71}
}
Periplasmic membrane fusion proteins (MFPs) are essential components of multidrug efflux pumps and type I protein secretion systems of gram-negative bacteria. Located in the periplasm, MFPs function by creating a physical link between inner membrane transporters and outer membrane channels. The most conserved sequence of MFPs is located in their distal C-terminal domain. However, neither the structure nor the function of this domain is known. In this study, we investigated the structural and… CONTINUE READING