The C-terminal domain is essential for protective activity of the Bordetella pertussis adenylate cyclase-hemolysin.

@article{Betsou1995TheCD,
  title={The C-terminal domain is essential for protective activity of the Bordetella pertussis adenylate cyclase-hemolysin.},
  author={F Betsou and Peter {\vS}ebo and Nicole Guiso},
  journal={Infection and immunity},
  year={1995},
  volume={63 9},
  pages={3309-15}
}
The adenylate cyclase-hemolysin of Bordetella pertussis consists of a cell-invasive N-terminal adenylate cyclase domain linked to a C-terminal RTX hemolysin containing extensive glycine-rich repeats. The toxin is an essential virulence factor required in the initial stages of infection. Adenylate cyclase-hemolysin was also shown to be a potent vaccinating antigen inducing protection against B. pertussis colonization of the mouse respiratory tract. This protective activity depends on a… CONTINUE READING

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