The C-terminal calcium-sensitive disordered motifs regulate isoform-specific polymerization characteristics of calsequestrin.

@article{Bal2015TheCC,
  title={The C-terminal calcium-sensitive disordered motifs regulate isoform-specific polymerization characteristics of calsequestrin.},
  author={Naresh Chandra Bal and Nivedita Jena and Harapriya Chakravarty and Amit Kumar and Mei Juan Chi and Tuniki Balaraju and Sharad V. Rawale and Jayashree S Rawale and Ashoke Sharon and Muthu Periasamy},
  journal={Biopolymers},
  year={2015},
  volume={103 1},
  pages={15-22}
}
Calsequestrin (CASQ) exists as two distinct isoforms CASQ1 and CASQ2 in all vertebrates. Although the isoforms exhibit unique functional characteristic, the structural basis for the same is yet to be fully defined. Interestingly, the C-terminal region of the two isoforms exhibit significant differences both in length and amino acid composition; forming Dn… CONTINUE READING