The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1

@inproceedings{Samad2011TheCB,
  title={The C-terminal basic residues contribute to the chemical- and
                    voltage-dependent activation of TRPA1},
  author={Abdul Samad and Lucie Sura and Jan Benedikt and R{\"u}diger H Ettrich and Babak Minofar and Jan Teisinger and Viktorie Vlachova},
  booktitle={The Biochemical journal},
  year={2011}
}
The ankyrin transient receptor potential channel TRPA1 is a non-selective cationic channel that is expressed by sensory neurons, where it can be activated by pungent chemicals, such as AITC (allyl isothiocyanate), cinnamon or allicin, by deep cooling (<18 °C) or highly depolarizing voltages (>+100 mV). From the cytoplasmic side, this channel can be regulated by negatively charged ligands such as phosphoinositides or inorganic polyphosphates, most likely through an interaction with as yet… CONTINUE READING
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