The C region of human insulin-like growth factor (IGF) I is required for high affinity binding to the type 1 IGF receptor.

@article{Bayne1989TheCR,
  title={The C region of human insulin-like growth factor (IGF) I is required for high affinity binding to the type 1 IGF receptor.},
  author={Marvin L. Bayne and J Applebaum and D R Underwood and Gary G. Chicchi and Barbara G Green and Nancy S Hayes and Margaret A. Cascieri},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 19},
  pages={11004-8}
}
We have produced and characterized the binding properties of three structural analogs of human insulin-like growth factor I (hIGF-I). These analogs are [1-62]hIGF-I, an analog lacking the carboxyl-terminal 8-amino acid D region of hIGF-I; [1-27, Gly4, 38-70]hIGF-I, an analog in which residues 28-37 of the C region of hIGF-I are replaced by a 4-reside glycine bridge; and [1-27,Gly4,38-62]hIGF-I, an analog with the C region glycine replacement and a D region deletion. The removal of the D region… CONTINUE READING

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