The C and E subunits of the serotonin 5-HT3 receptor subtly modulate electrical properties of the receptor.

@article{Yaakob2018TheCA,
  title={The C and E subunits of the serotonin 5-HT3 receptor subtly modulate electrical properties of the receptor.},
  author={Nor S Yaakob and D. Nguyen and Betty Exintaris and Helen R. Irving},
  journal={Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year={2018},
  volume={97},
  pages={
          1701-1709
        }
}
  • N. Yaakob, D. Nguyen, +1 author H. Irving
  • Published 2018
  • Chemistry, Medicine
  • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Serotonin type 3 (5-hydroxytrptamine-3, 5-HT3) receptors are ligand-gated cation channels present in both central and peripheral nervous systems. In humans there are five different subunits (A, B, C, D and E) of 5-HT3 receptors which can form homomeric or heteromeric receptors that may account for discrepancies in patient responses to treatments. The present study commences characterisation of the profiles of human 5-HT3 receptors containing C and/or E subunits. Recombinant 5-HT3 receptors were… Expand
3 Citations
Visualising functional 5-HT3 receptors containing A and C subunits at or near the cell surface.
TLDR
Examination of interactions of A and C subunits using 5-HT3 receptor subunits containing fluorescent protein inserts between the 3rd and 4th transmembrane spanning region shows that both A homomers and AC heteromers contribute to whole cell currents in response to 5- HT with minimal contribution from C homomers. Expand
Tapping into 5-HT3 Receptors to Modify Metabolic and Immune Responses
TLDR
The potential for targeting 5-HT3 receptors in conditions involving metabolic or inflammatory disorders based on recent findings is assessed, underscoring the challenges and limitations of this approach. Expand
Invertebrate serotonin receptors: a molecular perspective on classification and pharmacology
  • A. Tierney
  • Biology, Medicine
  • Journal of Experimental Biology
  • 2018
TLDR
An overview of heterologously expressed receptors is provided, which considers evolutionary relationships among them, classification based on these relationships and nomenclature that reflects classification, and transduction pathways and pharmacological profiles are compared. Expand

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