The C-Terminal Domain of TolA Is the Coreceptor for Filamentous Phage Infection of E. coli

@article{Riechmann1997TheCD,
  title={The C-Terminal Domain of TolA Is the Coreceptor for Filamentous Phage Infection of E. coli},
  author={Lutz Riechmann and Philipp Holliger},
  journal={Cell},
  year={1997},
  volume={90},
  pages={351-360}
}
Filamentous bacteriophages infecting gram-negative bacteria display tropism for a variety of pilus structures. However, the obligatory coreceptor of phage infection, postulated from genetic studies, has remained elusive. Here we identify the C-terminal domain of the periplasmic protein TolA as the coreceptor for infection of Escherichia coli by phage fd and the N-terminal domain of the phage minor coat protein g3p as its cognate ligand. The neighboring g3p domain binds the primary receptor of… CONTINUE READING

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