The C-Terminal Domain of TolA Is the Coreceptor for Filamentous Phage Infection of E. coli

  title={The C-Terminal Domain of TolA Is the Coreceptor for Filamentous Phage Infection of E. coli},
  author={Lutz Riechmann and Philipp Holliger},
Filamentous bacteriophages infecting gram-negative bacteria display tropism for a variety of pilus structures. However, the obligatory coreceptor of phage infection, postulated from genetic studies, has remained elusive. Here we identify the C-terminal domain of the periplasmic protein TolA as the coreceptor for infection of Escherichia coli by phage fd and the N-terminal domain of the phage minor coat protein g3p as its cognate ligand. The neighboring g3p domain binds the primary receptor of… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 51 references

TolA: a membrane protein involved in colicin uptake contains an extended helical region.

Proceedings of the National Academy of Sciences of the United States of America • 1991
View 5 Excerpts
Highly Influenced

Pore-forming properties of the adsorption protein of filamentous phage fd.

Biochimica et biophysica acta • 1989
View 2 Excerpts
Highly Influenced

Filamentous bacteriophage

P. Model, M. Russel
The Bacteriophages, R. Calendar, ed. (New York: Plenum Press), pp. 375–456. • 1988
View 4 Excerpts
Highly Influenced

Gene - III protein of filamen - of the TNF / NGF receptor family

J. W. Crissman, G. P. Smith
Cell • 1984
View 1 Excerpt
Highly Influenced

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