The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children.

@article{Clappier2007TheCL,
  title={The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children.},
  author={Emmanuelle Clappier and Wendy Cuccuini and Anna Kalota and Antoine Crinquette and J. -M. Cayuela and Willem A. Dik and Anton W. Langerak and Bertrand Montpellier and Bertrand Nadel and Pierre Walrafen and Olivier Delattre and Alain Aurias and Thierry Leblanc and Herv{\'e} Dombret and Alan M. Gewirtz and Andr{\'e} Baruchel and François Sigaux and J Steve Soulier},
  journal={Blood},
  year={2007},
  volume={110 4},
  pages={1251-61}
}
The C-Myb transcription factor is essential for hematopoiesis, including in the T-cell lineage. The C-Myb locus is a common site of retroviral insertional mutagenesis, however no recurrent genomic involvement has been reported in human malignancies. Here, we identified 2 types of genomic alterations involving the C-MYB locus at 6q23 in human T-cell acute leukemia (T-ALL). First, we found a reciprocal translocation, t(6;7)(q23;q34), that juxtaposed the TCRB and C-MYB loci (n = 6 cases). Second… CONTINUE READING