The C Factor: Cognitive dysfunction as a transdiagnostic dimension in psychopathology.

  title={The C Factor: Cognitive dysfunction as a transdiagnostic dimension in psychopathology.},
  author={Amitai Abramovitch and Tatiana Short and Avraham Schweiger},
  journal={Clinical psychology review},

Neurocognitive functioning in bipolar disorder: What we know and what we don’t

Evidence from available prospective studies does not support the notion of progressive cognitive decline in Bipolar Disorder while some evidence exists to suggest patients may show some improvements in cognitive functioning following the first manic episode.

Neuropsychological Research in Obsessive-Compulsive Disorder: Current Status and Future Directions

Neuropsychological functions in obsessive-compulsive disorder (OCD) have been extensively investigated. Despite some common findings across studies indicating deficient test performance across

Executive Functioning Constructs in Anxiety, Obsessive–Compulsive, Post-Traumatic Stress, and Related Disorders

Purpose of Review We synthesize theories proposing complex relations between cognitive functioning and anxiety-related concepts. We evaluate vulnerability theories suggesting that deficits in various

The magnitude of neurocognitive impairment is overestimated in depression: the role of motivation, debilitating momentary influences, and the overreliance on mean differences.

This study confirms that neurocognitive impairment in depression is likely overestimated; future studies should consider fair test-taking conditions and advise researchers to report percentages of patients showing performance deficits rather than relying solely on overall group differences.

Neurocognition and its association with adverse childhood experiences and familial risk of mental illness

The impact of childhood adversity on neurocognition is moderated by familial risk of psychiatric disorders, particularly in FDRs of patients with severe mental illness.

Cognitive function in clinical burnout: A systematic review and meta-analysis

It is suggested that clinical burnout is associated with cognitive impairment across multiple cognitive domains and cognitive dysfunction needs to be considered in the clinical and occupational health management of burnout to optimise rehabilitation and support return-to-work.

Investigating the Link Between Depression, Cognition, and Motivation in Late Childhood.

Cognitive deficits are not strongly associated with depression in childhood, in contrast with the impairment commonly seen in older individuals with depression.

Executive dysfunction in eating disorders: Relationship with clinical features



The p Factor

  • A. CaspiR. Houts T. Moffitt
  • Psychology
    Clinical psychological science : a journal of the Association for Psychological Science
  • 2014
The structure of psychopathology is examined, taking into account dimensionality, persistence, co-occurrence, and sequential comorbidity of mental disorders across 20 years, from adolescence to midlife, to explain why it is challenging to find causes, consequences, biomarkers, and treatments with specificity to individual mental disorders.

A meta-analysis of neuropsychological functioning in first-episode bipolar disorders.

Extending the 'cross-disorder' relevance of executive functions to dimensional neuropsychiatric traits in youth.

It is suggested that higher-order cognition, including EFs, relates to the dimensional spectrum of each of these disorders and not just the clinical diagnoses, which has implications for bottom-up models linking genes, cognition, and a general psychopathology liability.

Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review.

It is demonstrated that major depressive disorder is reliably associated with impaired performance on neuropsychological measures of EF, and the results are consistent with the theory that MDD is associated with broad impairment in multiple aspects of EF.

Cognitive functioning in obsessive-compulsive disorder: a meta-analysis

Patients with OCD appear to have wide-ranging cognitive deficits, although their impairment is not so large in general, indicating the need to select carefully the test forms and methods of testing used in future research.

Cognitive impairment in depression: a systematic review and meta-analysis

It is argued that remediation of cognitive impairment and alleviation of depressive symptoms each play an important role in improving outcome for patients with depression, and cognitive impairment represents a core feature of depression that cannot be considered an epiphenomenon that is entirely secondary to symptoms of low mood.