The Bv8 gene from Bombina orientalis: molecular cloning, genomic organization and functional characterization of the promoter.

@article{Marsango2009TheBG,
  title={The Bv8 gene from Bombina orientalis: molecular cloning, genomic organization and functional characterization of the promoter.},
  author={Sara Marsango and Maria Carmela Bonaccorsi di Patti and Donatella Barra and Rossella Miele},
  journal={Peptides},
  year={2009},
  volume={30 12},
  pages={2182-90}
}
Bv8 is a secreted peptide from Bombina variegata skin glands with a molecular mass close to 8kDa that is conserved in fish, amphibians and mammals. Bv8 has diverse regulatory roles, including an involvement in hematopoiesis and immunomodulation. Here we report the genomic organization of the gene from Bombina orientalis coding for the Bv8 homolog (Bo8). It contains three exons separated by two large introns. Several putative transcription factor binding sites have been identified in the… CONTINUE READING
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