The Burkholderia pseudomallei Type III Secretion System and BopA Are Required for Evasion of LC3-Associated Phagocytosis

@inproceedings{Gong2011TheBP,
  title={The Burkholderia pseudomallei Type III Secretion System and BopA Are Required for Evasion of LC3-Associated Phagocytosis},
  author={Lan Gong and M{\'e}abh Cullinane and Puthayalai Treerat and Georg Ramm and Mark Prescott and Ben Adler and John D Boyce and Rodney J Devenish},
  booktitle={PloS one},
  year={2011}
}
Burkholderia pseudomallei is the causative agent of melioidosis, a fatal infectious disease endemic in tropical regions worldwide, and especially prevalent in southeast Asia and northern Australia. This intracellular pathogen can escape from phagosomes into the host cytoplasm, where it replicates and infects adjacent cells. We previously demonstrated that, in response to B. pseudomallei infection of macrophage cell line RAW 264.7, a subset of bacteria co-localized with the autophagy marker… CONTINUE READING
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