The Budd-Chiari syndrome caused by a zygomycete. A new pathogenesis of hepatic vein thrombosis.

Abstract

The clinical history of a 60-year-old woman suffering from chronic lymphocytic leukemia with sudden deterioration and death is reported. The postmortem macroscopic and microscopic findings included pulmonary aspergillosis and pulmonary zygomycosis (mucormycosis). Hematogenous dissemination of the zygomycete causing cardiac zygomycosis, cerebral infarcts due to vascular occlusion by hyphae, and thrombosis of the major hepatic veins (Budd-Chiari syndrome) with submassive necrosis of the right liver lobe were also observed. To our knowledge, this is the second report dealing with occlusion of the hepatic veins caused by a fungus and the first study reporting the Budd-Chiari syndrome due to a mold of the subclass Zygomycetes.

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@article{Vallaeys1989TheBS, title={The Budd-Chiari syndrome caused by a zygomycete. A new pathogenesis of hepatic vein thrombosis.}, author={J. H. J. Vallaeys and Marleen M Praet and Hendrik J L Roels and E A Van marck and Lea Kaufman}, journal={Archives of pathology & laboratory medicine}, year={1989}, volume={113 10}, pages={1171-4} }