The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles

@inproceedings{Matkovi2013TheBC,
  title={The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles},
  author={Tanja Matkovi{\'c} and Matthias Siebert and Elena Knoche and Harald Depner and Sara Mertel and David Owald and Manuela Schmidt and Ulrich Thomas and Albert Sickmann and Dirk Kamin and Stefan W Hell and J{\"o}rg B{\"u}rger and Christina Hollmann and Thorsten Mielke and Carolin Wichmann and Stephan J. Sigrist},
  booktitle={The Journal of cell biology},
  year={2013}
}
Synaptic vesicles (SVs) fuse at a specialized membrane domain called the active zone (AZ), covered by a conserved cytomatrix. How exactly cytomatrix components intersect with SV release remains insufficiently understood. We showed previously that loss of the Drosophila melanogaster ELKS family protein Bruchpilot (BRP) eliminates the cytomatrix (T bar) and declusters Ca(2+) channels. In this paper, we explored additional functions of the cytomatrix, starting with the biochemical identification… CONTINUE READING

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