The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation.

@article{Pastori2015TheBP,
  title={The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation.},
  author={Chiara Pastori and Philipp Kapranov and Clara Penas and Veronica Julia Peschansky and Claude-Henry Volmar and Jann N. Sarkaria and Amade Bregy and Ricardo J. Komotar and Georges C St Laurent and Nagi George Ayad and Claes Wahlestedt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 27},
  pages={8326-31}
}
Bromodomain and extraterminal (BET) domain proteins have emerged as promising therapeutic targets in glioblastoma and many other cancers. Small molecule inhibitors of BET bromodomain proteins reduce expression of several oncogenes required for Glioblastoma Multiforme (GBM) progression. However, the mechanism through which BET protein inhibition reduces GBM growth is not completely understood. Long noncoding RNAs (lncRNAs) are important epigenetic regulators with critical roles in cancer… CONTINUE READING
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