The Bright and the Dark Sides of DNA Repair in Stem Cells

@inproceedings{Frsina2010TheBA,
  title={The Bright and the Dark Sides of DNA Repair in Stem Cells},
  author={Guido Fr{\`o}sina},
  booktitle={Journal of biomedicine & biotechnology},
  year={2010}
}
DNA repair is a double-edged sword in stem cells. It protects normal stem cells in both embryonic and adult tissues from genetic damage, thus allowing perpetuation of intact genomes into new tissues. Fast and efficient DNA repair mechanisms have evolved in normal stem and progenitor cells. Upon differentiation, a certain degree of somatic mutations becomes more acceptable and, consequently, DNA repair dims. DNA repair turns into a problem when stem cells transform and become cancerous… CONTINUE READING