878 Citations
The Neuroscience of Drug Reward and Addiction.
- Psychology, BiologyPhysiological reviews
- 2019
Treatment interventions intended to reverse neuroadaptations that result in an impaired prefrontal top-down self-regulation that favors compulsive drug-taking against the backdrop of negative emotionality and an enhanced interoceptive awareness of "drug hunger" show promise as therapeutic approaches for addiction.
Ethology of Addiction and Dopamine
- Psychology, Biology
- 2020
The addictive effect of substances develops in the brain with increased dopamine secreted by dopaminergic neurons from the ventral tegmental area to the nucleus accumbens.
Neurobiology of addiction: a neurocircuitry analysis.
- Psychology, BiologyThe lancet. Psychiatry
- 2016
Neuroinflammatory Response in Reward-Associated Psychostimulants and Opioids: A Review.
- Biology, PsychologyCellular and molecular neurobiology
- 2022
Research in the alterations of inflammatory responses accompanied by rewarding and reinforcing properties of addictive drugs, including cocaine, methamphetamine, and opioids that were evaluated by conditioned place preference and self-administration procedures as highly common behavioral tests to investigate the motivational and reinforcing impacts of addicted drugs are summarized.
Neurobiologic Advances from the Brain Disease Model of Addiction.
- Psychology, MedicineThe New England journal of medicine
- 2016
It is concluded that neuroscience continues to support the brain disease model of addiction, which has led to the development of more effective methods of prevention and treatment and to more informed public health policies.
Sufficiency of Mesolimbic Dopamine Neuron Stimulation for the Progression to Addiction
- Biology, PsychologyNeuron
- 2015
Reward Circuitry in Addiction
- Biology, PsychologyNeurotherapeutics
- 2017
Current understanding of the major brain regions implicated in drug-related behaviors and the molecular mechanisms that contribute to altered connectivity between these regions are summarized, with the postulation that increased knowledge of the plasticity within the drug reward circuit will lead to new and improved treatments for addiction.
Neurocircuitry of Reward and Addiction: Potential Impact of Dopamine–Glutamate Co-release as Future Target in Substance Use Disorder
- Biology, PsychologyJournal of clinical medicine
- 2019
Several studies implementing conditional knockout and optogenetics technologies in transgenic mice have during the past decade pointed towards a role for glutamate co-release in multiple physiological and behavioral processes of importance to substance use and abuse.
Individual differences in the neuropsychopathology of addiction
- Psychology, BiologyDialogues in clinical neuroscience
- 2017
Characterization of the neuropsychological mechanisms that underlie individual differences in addiction-like behaviors is the key to understanding the mechanisms of addiction and development of personalized pharmacotherapy.
References
SHOWING 1-10 OF 190 REFERENCES
Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction
- Biology, PsychologyPhilosophical Transactions of the Royal Society B: Biological Sciences
- 2008
Evidence showing that impulsivity, a spontaneously occurring behavioural tendency in outbred rats that is associated with low dopamine D2/3 receptors in the nucleus accumbens, predicts both the propensity to escalate cocaine intake and the switch to compulsive drug seeking and addiction is summarized.
Addiction: Beyond dopamine reward circuitry
- Psychology, BiologyProceedings of the National Academy of Sciences
- 2011
Results point to an imbalance between dopaminergic circuits that underlie reward and conditioning and those thatUnderlie executive function (emotional control and decision making), which contributes to the compulsive drug use and loss of control in addiction.
Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex.
- Biology, PsychologyCerebral cortex
- 2000
It is implied that pleasure per se is not enough to maintain compulsive drug administration in the drugaddicted subject and that drugs that could interfere with the activation of the striato-thalamo-orbitofrontal circuit could be beneficial in the treatment of drug addiction.
Integrating synaptic plasticity and striatal circuit function in addiction
- Biology, PsychologyCurrent Opinion in Neurobiology
- 2012
Current perspectives on selective dopamine D3 receptor antagonists as pharmacotherapeutics for addictions and related disorders
- Biology, PsychologyAnnals of the New York Academy of Sciences
- 2010
Preclinical evidence in support of the efficacy of selective DA D3 receptor antagonists in animal models of drug addiction will be reviewed and translational research from preclinical efficacy studies to so‐called proof‐of‐concept studies for drug addiction indications will be discussed.
Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use
- Biology, PsychologyNature Neuroscience
- 2013
Results indicate that recruitment of D2-MSNs in NAc functions to restrain cocaine self-administration and serves as a natural protective mechanism in drug-exposed individuals.
Addiction: a disease of learning and memory.
- Psychology, BiologyThe American journal of psychiatry
- 2005
Evidence at the molecular, cellular, systems, behavioral, and computational levels of analysis is converging to suggest the view that addiction represents a pathological usurpation of the neural mechanisms of learning and memory that under normal circumstances serve to shape survival behaviors related to the pursuit of rewards and the cues that predict them.
Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors.
- Biology, MedicinePharmacology & therapeutics
- 2011
Drug-Evoked Synaptic Plasticity in Addiction: From Molecular Changes to Circuit Remodeling
- BiologyNeuron
- 2011
Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction
- Biology, PsychologyFront. Cell. Neurosci.
- 2015
How neurobiological changes produced by drugs of abuse may provide novel targets for potential treatment strategies for addiction are discussed.