The Brain on Drugs: From Reward to Addiction

  title={The Brain on Drugs: From Reward to Addiction},
  author={Nora D. Volkow and Marisela Morales},
Advances in neuroscience identified addiction as a chronic brain disease with strong genetic, neurodevelopmental, and sociocultural components. We here discuss the circuit- and cell-level mechanisms of this condition and its co-option of pathways regulating reward, self-control, and affect. Drugs of abuse exert their initial reinforcing effects by triggering supraphysiologic surges of dopamine in the nucleus accumbens that activate the direct striatal pathway via D1 receptors and inhibit the… CONTINUE READING
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