The Brachyspira hyodysenteriae ftnA Gene: DNA Vaccinationand Real-Time PCR Quantification of Bacteria in a Mouse Modelof Disease

@article{Davis2005TheBH,
  title={The Brachyspira hyodysenteriae ftnA Gene: DNA Vaccinationand Real-Time PCR Quantification of Bacteria in a Mouse Modelof Disease},
  author={Antony J. Davis and Stuart C. Smith and Robert J Moore},
  journal={Current Microbiology},
  year={2005},
  volume={50},
  pages={285-291}
}
The nucleotide sequence of the Brachyspira hyodysenteriae ftnA gene, encoding a putative ferritin protein (FtnA), was determined. Analysis of the sequence predicted that this gene encoded a protein of 180 amino acids. RT-PCR and Western blot showed that the ftnA gene was expressed in B. hyodysenteriae, and evidence suggests that FtnA stores iron rather than haem. ftnA was delivered as DNA and recombinant protein vaccines in a mouse model of B. hyodysenteriae infection. Vaccine efficacy was… CONTINUE READING
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