The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA

Abstract

The product of the gene mutated in Bloom's syndrome, BLM, is a 3'-5' DNA helicase belonging to the highly conserved RecQ family. In addition to a conventional DNA strand separation activity, BLM catalyzes both the disruption of non-B-form DNA, such as G-quadruplexes, and the branch migration of Holliday junctions. Here, we have characterized a new activity… (More)

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@article{Cheok2005TheBS, title={The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA}, author={Chit Fang Cheok and Leonard Wu and Patrick L. Garcia and Pavel Janscak and Ian D. Hickson}, journal={Nucleic Acids Research}, year={2005}, volume={33}, pages={3932 - 3941} }