The Bloom's syndrome helicase can promote the regression of a model replication fork.

@article{Ralf2006TheBS,
  title={The Bloom's syndrome helicase can promote the regression of a model replication fork.},
  author={Christine Ralf and Ian D. Hickson and Leonard Wu},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 32},
  pages={22839-46}
}
Homozygous inactivation of BLM gives rise to Bloom's syndrome, a disorder associated with genomic instability and cancer predisposition. BLM encodes a member of the RecQ DNA helicase family that is required for the maintenance of genome stability and the suppression of sister-chromatid exchanges. BLM has been proposed to function in the rescue of replication forks that have collapsed or stalled as a result of encountering lesions that block fork progression. One proposed mechanism of fork… CONTINUE READING

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