The Bloom's syndrome gene product is homologous to RecQ helicases


The Bloom's syndrome (BS) gene, BLM, plays an important role in the maintenance of genomic stability in somatic cells. A candidate for BLM was identified by direct selection of a cDNA derived from a 250 kb segment of the genome to which BLM had been assigned by somatic crossover point mapping. In this novel mapping method, cells were used from persons with… (More)
DOI: 10.1016/0092-8674(95)90105-1

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