The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

  title={The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders},
  author={Berislav V Zlokovic},
The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully differentiated neurovascular system. In concert with pericytes, astrocytes, and microglia, the BBB separates components of the circulating blood from neurons. Moreover, the BBB maintains the chemical composition of the neuronal "milieu," which is required for proper functioning of neuronal circuits, synaptic transmission, synaptic remodeling, angiogenesis, and neurogenesis in the adult brain. BBB… CONTINUE READING
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