The Biology of Human Resilience: Opportunities for Enhancing Resilience Across the Life Span

  title={The Biology of Human Resilience: Opportunities for Enhancing Resilience Across the Life Span},
  author={Adriana Feder and Sharely Fred-Torres and Steven M. Southwick and Dennis S. Charney},
  journal={Biological Psychiatry},

Resilience in the age of COVID-19

This review seeks to understand resilience as a complex and active process that is shaped by neurobiological profiles, developmental experiences, cultural and temporal contexts, and practical training and uses the COVID-19 pandemic as a case example to better understand individual and group responses to tragedy.

Early-Life Trauma and Resilience: Insights From Developmental Neuroscience for Policy.

  • D. Gee
  • Psychology
    Biological psychiatry. Cognitive neuroscience and neuroimaging
  • 2020

Low Psychological Resilience in Older Individuals: An Association with Increased Inflammation, Oxidative Stress and the Presence of Chronic Medical Conditions

This paper aims to reveal, through a translational approach, physiological and molecular mechanisms of emotional distress and low psychological resilience in older individuals as driving mechanisms for the accelerated development of chronic aging diseases, and to systematize the available information sources on strategies for mitigation of low resilience in order to prevent chronic diseases.

The Etiology of Resilience to Disadvantage.

Background Although early-life exposure to chronic disadvantage is associated with deleterious outcomes, 40-60% of exposed youth continue to thrive. To date, little is known about the etiology of

Resilience beyond reductionism: ethical and social dimensions of an emerging concept in the neurosciences

It is argued that especially one-sided understandings of resilience which dismiss social and cultural contexts of personal resilience do pose social and ethical problems and bioethics should take a closer look at resilience and resilience research, which are today philosophically under-theorized.

System models for resilience in gerontology: application to the COVID-19 pandemic

The National Academies of Science conceptualization of resilience for natural disasters to frame resilience for aging adults enables development of a generalized theory of resilient for different individual and structural contexts and populations, including a specific application to the COVID-19 pandemic.

Advancing research on early autism through an integrated risk and resilience perspective.

To date, a deficit-oriented approach dominates autism spectrum disorder (ASD) research, including studies of infant siblings of children with ASD at high risk (HR) for the disabilities associated

Resilience in 2021—Descriptive Analysis of Individuals Accessing Virtual Mental Health Services: Retrospective Observational Study

Overall, members had low baseline resilience, similar to resilience levels observed in trauma survivors in prior studies, suggesting a need for mental health support among individuals who might not typically be recommended for treatment based on traditional clinical assessments.

Psychological resilience: an update on definitions, a critical appraisal, and research recommendations

Increasingly sophisticated and nuanced conceptual frameworks, coupled with research leveraging advances in genetics, molecular biology, increased computational capacity, and larger, more diverse datasets suggest that the next decade of research could bring significant breakthroughs.

Resilience to the effects of social stress on vulnerability to developing drug addiction

The current knowledge on the neurobiological substrates of resilience derived from studies of resilience to the effects of chronic SD stress on depression- and anxiety-related behaviors in rodents is summarized.



Understanding Resilience and Preventing and Treating PTSD.

This review summarizes the vast field of resilience research spanning genomic, psychosocial, and neurobiological levels, and discusses how findings have led and can lead to new preventive and treatment interventions for PTSD.

Resilience to adversity and the early origins of disease

A recent expansion of research using longitudinal, epidemiological studies and randomized prevention trials to test hypotheses about the origins of disease among rural African American youths is described, demonstrating that family-centered prevention programs can have health benefits by reducing inflammation, helping to preserve telomere length, and inhibiting epigenetic aging.

Resilience: The Science of Mastering Life's Greatest Challenges

Most of us at some point in our lives will be struck by major traumas such as the sudden death of a loved one, a debilitating disease, assault, or a natural disaster. Resilience refers to the ability

Plasticity of the epigenome during early-life stress.

Stress Response Modulation Underlying the Psychobiology of Resilience

Significant aspects of stress response modulation related to early life development and epigenetics, selected neurobiological and neurochemical systems, and a number of emotional, cognitive, psychosocial, and behavioral factors important in resilience are highlighted.

Resilience definitions, theory, and challenges: interdisciplinary perspectives

In this paper, inspired by the plenary panel at the 2013 meeting of the International Society for Traumatic Stress Studies, Dr. Steven Southwick (chair) and multidisciplinary panelists Drs. George

Structural brain correlates of adolescent resilience.

The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation.

Psychiatric resilience: longitudinal twin study

Both genes and environment influence level of psychiatric resilience, and are largely stable over time, and can have an enduring effect on resilience.