The Biology of CRISPR-Cas: Backward and Forward
@article{Hille2018TheBO,
title={The Biology of CRISPR-Cas: Backward and Forward},
author={Frank Hille and Hagen Richter and Shi Pey Wong and Majda Bratovi{\vc} and Sarah Ressel and Emmanuelle Charpentier},
journal={Cell},
year={2018},
volume={172},
pages={1239-1259}
}389 Citations
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The CRISPR-Cas system gained popularity after it was proposed as a tool for plant and animal embryo editing, in cancer therapy, as antimicrobial against pathogenic bacteria, and even for combating the novel coronavirus - SARS-CoV-2; thus, the newest and promising applications are reviewed.
Structural basis of CRISPR-Cas Type III prokaryotic defence systems.
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CRISPR-Cas in Escherichia coli: regulation by H-NS, LeuO and temperature
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The role of temperature in the regulation of the CRISPR-Cas activity and the interplay of the key regulators H-NS and StpA repressors and LeuO antirepressor in regulation of cas gene expression and HtpG chaperone in maintaining functional levels of Cas3 are given.
A moonlighting nuclease puts CRISPR in its place
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It is shown that in subtype I-E systems, Cas4-like activity is supplied by DnaQ-superfamily exonucleases, providing a beautiful example of cellular machinery moonlighting in support of CRISPR-Cas adaptive immunity.
Conquering CRISPR: how phages overcome bacterial adaptive immunity.
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Identification and Characterization of the CRISPR/Cas System in Staphylococcus aureus Strains From Diverse Sources
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Findings indicate that antibiotic phages proposed as an alternative therapy in biofilm-forming or infection with S. aureus strains would be ineffective and more research about the CRISPR/Cas system is necessary.
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