The Biology of CRISPR-Cas: Backward and Forward

@article{Hille2018TheBO,
  title={The Biology of CRISPR-Cas: Backward and Forward},
  author={Frank Hille and Hagen Richter and S. Wong and Majda Bratovi{\vc} and Sarah Ressel and E. Charpentier},
  journal={Cell},
  year={2018},
  volume={172},
  pages={1239-1259}
}
In bacteria and archaea, clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system against phages and other foreign genetic elements. Here, we review the biology of the diverse CRISPR-Cas systems and the major progress achieved in recent years in understanding the underlying mechanisms of the three stages of CRISPR-Cas immunity: adaptation, crRNA biogenesis, and interference. The ecology and regulation of CRISPR… Expand
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References

SHOWING 1-10 OF 240 REFERENCES
Evolution and Ecology of CRISPR
CRISPR–Cas systems: beyond adaptive immunity
Unravelling the structural and mechanistic basis of CRISPR–Cas systems
Inhibition of CRISPR-Cas systems by mobile genetic elements.
Evolution and classification of the CRISPR–Cas systems
Regulation of CRISPR-Cas adaptive immune systems.
CRISPR-Cas
CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes
Cas9 function and host genome sampling in Type II-A CRISPR-Cas adaptation.
...
1
2
3
4
5
...