The Biology of Bone Metastasis.

@article{Esposito2018TheBO,
  title={The Biology of Bone Metastasis.},
  author={Mark Esposito and Theresa A. Guise and Yibin Kang},
  journal={Cold Spring Harbor perspectives in medicine},
  year={2018},
  volume={8 6}
}
Bone metastasis, or the development of secondary tumors within the bone of cancer patients, is a debilitating and incurable disease. Despite its morbidity, the biology of bone metastasis represents one of the most complex and intriguing of all oncogenic processes. This complexity derives from the intricately organized bone microenvironment in which the various stages of hematopoiesis, osteogenesis, and osteolysis are jointly regulated but spatially restricted. Disseminated tumor cells (DTCs… CONTINUE READING
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