The Biological Outcome of CD 40 Signaling Is Dependent on the Duration of CD 40 Ligand Expression : Reciprocal Regulation by Interleukin ( IL )-4 and IL-12

@inproceedings{Lee2002TheBO,
  title={The Biological Outcome of CD 40 Signaling Is Dependent on the Duration of CD 40 Ligand Expression : Reciprocal Regulation by Interleukin ( IL )-4 and IL-12},
  author={Byung Ok Lee and Laura Haynes and Sheri M. Eaton and Susan L Swain and Troy D. Randall},
  year={2002}
}
CD40 ligand (CD154) expression on activated T cells can be separated into an early TCRdependent phase, which occurs between 0 and 24 h after activation, and a later extended phase, which occurs after 24 h and is reciprocally regulated by the cytokines IL-4 and IL-12. IL-4 represses, whereas IL-12 sustains CD154 expression. Consistent with this, Th1, but not… CONTINUE READING