The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature

@inproceedings{Xiong2014TheBF,
  title={The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature},
  author={Lijuan Xiong and Carl Keith Edwards and Lijun Zhou},
  booktitle={International journal of molecular sciences},
  year={2014}
}
CD147 or EMMPRIN is a member of the immunoglobulin superfamily in humans. It is widely expressed in human tumors and plays a central role in the progression of many cancers by stimulating the secretion of matrix metalloproteinases (MMPs) and cytokines. CD147 regulates cell proliferation, apoptosis, and tumor cell migration, metastasis and differentiation, especially under hypoxic conditions. CD147 is also important to many organ systems. This review will provide a detailed overview of the… CONTINUE READING
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