The Biologic Clock: The Mitochondria?

@article{Harman1972TheBC,
  title={The Biologic Clock: The Mitochondria?},
  author={Denham Harman},
  journal={Journal of the American Geriatrics Society},
  year={1972},
  volume={20}
}
  • Denham Harman
  • Published 1 April 1972
  • Biology
  • Journal of the American Geriatrics Society
The author suggests that the maximal life span of a given mammalian species is largely an expression of genetic control over the rate of oxygen utilization. The latter determines the rate of accumulation of mitochondrial damage produced by free radical reactions, the rate increasing with the rate of oxygen consumption, which ultimately causes death. 
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