The Bioinformatics Analysis of Comparative Genomics of Mycobacterium tuberculosis Complex (MTBC) Provides Insight into Dissimilarities between Intraspecific Groups Differing in Host Association, Virulence, and Epitope Diversity

@inproceedings{Jia2017TheBA,
  title={The Bioinformatics Analysis of Comparative Genomics of Mycobacterium tuberculosis Complex (MTBC) Provides Insight into Dissimilarities between Intraspecific Groups Differing in Host Association, Virulence, and Epitope Diversity},
  author={Xinmiao Jia and Li Yang and Mengxing Dong and Suting Chen and Lingna Lv and Dandan Cao and Jing Li Fu and Tingting Yang and Ju Zhang and Xiangli Zhang and Yuanyuan Shang and Gui-Rong Wang and Yongjie Sheng and Hairong Huang and Fei Chen},
  booktitle={Front. Cell. Infect. Microbiol.},
  year={2017}
}
Tuberculosis now exceeds HIV as the top infectious disease cause of mortality, and is caused by the Mycobacterium tuberculosis complex (MTBC). MTBC strains have highly conserved genome sequences (similarity >99%) but dramatically different phenotypes. To analyze the relationship between genotype and phenotype, we conducted the comparative genomic analysis on 12 MTBC strains representing different lineages (i.e., Mycobacterium bovis; M. bovis BCG; M. microti; M. africanum; M. tuberculosis H37Rv… CONTINUE READING