The Bioidentical Hormone Debate: Are Bioidentical Hormones (Estradiol, Estriol, and Progesterone) Safer or More Efficacious than Commonly Used Synthetic Versions in Hormone Replacement Therapy?

@article{Holtorf2009TheBH,
  title={The Bioidentical Hormone Debate: Are Bioidentical Hormones (Estradiol, Estriol, and Progesterone) Safer or More Efficacious than Commonly Used Synthetic Versions in Hormone Replacement Therapy?},
  author={K. Holtorf},
  journal={Postgraduate Medicine},
  year={2009},
  volume={121},
  pages={73 - 85}
}
  • K. Holtorf
  • Published 2009
  • Medicine
  • Postgraduate Medicine
Abstract Background: The use of bioidentical hormones, including progesterone, estradiol, and estriol, in hormone replacement therapy (HRT) has sparked intense debate. Of special concern is their relative safety compared with traditional synthetic and animal-derived versions, such as conjugated equine estrogens (CEE), medroxyprogesterone acetate (MPA), and other synthetic progestins. Proponents for bioidentical hormones claim that they are safer than comparable synthetic and nonhuman versions… Expand

Paper Mentions

Observational Clinical Trial
Bioidentical Hormone Replacement Therapy (BHRT) to assess a change in the number of various menopausal symptoms such as hot flashes and night sweats in surgically or naturally induced… Expand
ConditionsMenopause
Investigating progesterone and estrogen receptor crosstalk in breast cancer
Bioidentical hormone therapy.
Beneficial aspect of oral estriol as hormone replacement therapy: consideration on bone and lipid metabolism.
Hormone Therapy and Breast Cancer: Emerging Steroid Receptor Mechanisms.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 272 REFERENCES
Progestins and progesterone in hormone replacement therapy and the risk of breast cancer
Comparison of the proliferative effects of estradiol and conjugated equine estrogens on human breast cancer cells and impact of continuous combined progestogen addition
Pregnancy, progesterone and progestins in relation to breast cancer risk
Effect of norethisterone acetate on estrogen metabolism in postmenopausal women.
  • H. Seeger, A. Mueck, T. Lippert
  • Medicine
  • Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 2000
Oral Progesterone and Estrogen/Progestogen Therapy: Effects of natural and synthetic hormones on subfractions of HDL cholesterol and liver proteins
  • U. B. Ottosson
  • Medicine
  • Acta obstetricia et gynecologica Scandinavica. Supplement
  • 1984
Effects of estrone, estradiol, and estriol on hormone-responsive human breast cancer in long-term tissue culture.
...
1
2
3
4
5
...