The Bioavailability and Nonlinear Clearance of (–)-Carbovir in the Rat

Abstract

The pharmacokinetics and bioavailability of (±)-carbovir, a carbocyclic nucleoside active against human immunodeficiency virus, have been described previously. To determine the bioavailability of (–)-carbovir, the biologically active enantiomer, four male Sprague–Dawley rats received 18 mg/kg of (–)-carbovir through the jugular vein and 54 mg/kg orally… (More)
DOI: 10.1023/A:1015850017201

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