The Bif-1-Dynamin 2 membrane fission machinery regulates Atg9-containing vesicle generation at the Rab11-positive reservoirs

@inproceedings{Takahashi2016TheB2,
  title={The Bif-1-Dynamin 2 membrane fission machinery regulates Atg9-containing vesicle generation at the Rab11-positive reservoirs},
  author={Yoshinori Takahashi and Nikolaos Tsotakos and Ying Liu and Megan M. Young and Jacob M Serfass and Zhenyuan Tang and Thomas Abraham and Hong-gang Wang},
  booktitle={Oncotarget},
  year={2016}
}
Atg9 is a multispanning transmembrane protein that is required for autophagosome formation. During autophagy, vesicles containing Atg9 are generated through an unknown mechanism and delivered to the autophagosome formation sites. We have previously reported that Atg9-containing membranes undergo continuous tubulation and fission during nutrient starvation in a manner dependent on the curvature-inducing protein Bif-1/Sh3glb1. Here, we identify Dynamin 2 (DNM2) as a Bif-1-interacting protein that… CONTINUE READING