The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification

@inproceedings{Sedlyarov2018TheBT,
  title={The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification},
  author={Vitaly Sedlyarov and Ruth Eichner and Enrico Girardi and Patrick Essletzbichler and Ulrich Goldmann and Paula Nunes-Hasler and Ismet Srndic and Anna Moskovskich and Leonhard X. Heinz and Felix Kartnig and Johannes W Bigenzahn and Manuele Rebsamen and Pavel Kovarik and Nicolas Demaurex and Giulio Superti-Furga},
  booktitle={Cell host & microbe},
  year={2018}
}
Macrophages represent the first line of immune defense against pathogens, and phagosome acidification is a necessary step in pathogen clearance. Here, we identified the bicarbonate transporter SLC4A7, which is strongly induced upon macrophage differentiation, as critical for phagosome acidification. Loss of SLC4A7 reduced acidification of phagocytosed beads or bacteria and impaired the intracellular microbicidal capacity in human macrophage cell lines. The phenotype was rescued by wild-type… CONTINUE READING